Exercise-induced hormone irisin triggers bone remodeling in mice

Exercise has been touted to build bone mass, but exactly how it actually accomplishes this is a matter of debate. Now, researchers show that an exercise-induced hormone activates cells that are critical for bone remodeling in mice. A study identifies a receptor for irisin, an exercise hormone, and shows that irisin impacts sclerostin in mice, a major cellular regulator of bone structure in humans.